Student Activity: Toward a More Sustainable Campus through Innovative Design and Practical Application
T Grape seed extract (GSE) is a complex mixture of several compounds, mostly represented by polyphenols and phenolic acids. The goal of the pilot study was to illustrate the safe dose of GSE in mice model and to assess toxicity that may be initiated by the different concentrations of this plant. Forty-two mice were divided equally into 7 groups; groups 1 attended as control, were only received water, whereas animals of groups 2, 3, 4 were treated orally with 200, 400, and 800 mg/kg b.w. of black grape seed extract respectively, and the remaining groups including 5, 6, and 7 were treated orally with 200, 400, and 800 mg/kg b.w. of red grape seed extract respectively. The animals were observed daily for any sign revealing for activity alterations and toxicity along with their body weight measurement during the experiment for 21 days with histopathological examination. The results gained from this pilot study were recording that the 200 and 400 mg/kg b.w. doses of GSE were safe compared to the 800 mg/kg b.w.in both black and red grape seed extracts because the higher dose led to a reduction in body weight gain and produce changes in the mentioned organs.
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