خوێندکارانی بەشی یاسا سەردانی بەڕێوەبەرایەتیی چاکسازیی ژنان و منداڵان – سلێمانى کرد
Asst. Prof. Dr. Hastyar H. Najmuldeen, Dean of the College of Health Sciences and Sima Rahman Qadir, a laboratory assistant at the same college in Cihan University–Sulaimaniya have published a new research article in the journal of Bioorganic Chemistry (Elsevier).
The study explores the potential of Salmonella typhi as a source of biologically active compounds with significant antimicrobial properties. The research focuses on metabolites secreted by clinically isolated S. typhi and evaluates their effectiveness against important multidrug-resistant (MDR) bacterial pathogens using comprehensive biochemical and analytical approaches.
The findings revealed that the crude metabolite extract exhibited strong growth-inhibitory and bactericidal activity, in addition to significantly reducing and disrupting biofilm formation in resistant bacterial strains. Notably, these antimicrobial effects persisted even after exposure to high temperatures, indicating that the active components are thermostable and predominantly non-proteinaceous. GC–MS profiling identified a chemically diverse mixture of fatty acids, diketopiperazines, and aromatic compounds, many of which are associated with membrane-disruptive and quorum-sensing–interfering properties. FT–IR analysis further confirmed the presence of distinctive functional groups consistent with low-molecular-weight bioactive metabolites.
This work provides the first documented evidence that S. typhi secretes stable, chemically diverse metabolites with potent antibacterial and antibiofilm activities, positioning the organism as an unconventional yet promising reservoir of new antimicrobial scaffolds. The authors emphasize that future studies will focus on purification, structural characterization, and mechanistic evaluations to support the development of these metabolites into safe and effective anti-infective agents.
The journal CiteScore is (8.3), Impact Factor (4.7). Ranked Q1 in Scopus.
The article can be found at the following link: https://doi.org/10.1016/j.bioorg.2025.109226
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