بەشی وەرگێڕانی زانکۆی جیهان سلێمانی ١٦ کۆمپیوتەری لاپتۆپی بەخشی بە خوێندکارانی بەشەکە
“Alteration of Antioxidant and Xenobiotic Metabolizing Enzyme Activities in Rainbow Trout (Oncorhynchus mykiss) Treated With Caffeine and Cotinine During the Spawning Season”
Assistant Lecturer Darya Shorsh Hamad at the Department of Anaesthesia, College of Health Sciences, Cihan University-Sulaimaniya, has published an article in the Journal of Applied Toxicology. This article provides new experimental evidence on how exposure to common environmental pollutants, caffeine and cotinine, affects the detoxification and antioxidant systems in rainbow trout during their sensitive spawning period. The study identifies significant, sex-specific alterations in key enzyme activities, including those of cytochrome P450s (CYP1A, CYP2B, CYP3A) and antioxidant enzymes like glutathione S transferase (GST) and glutathione peroxidase (GPx). The findings suggest that these pollutants can disrupt the metabolism of endogenous molecules, such as hormones, and impair the fish’s ability to detoxify other environmental contaminants. This work highlights the potential ecological risks posed by human-derived chemicals to aquatic organisms during critical life stages and underscores the importance of considering gender differences in ecotoxicological studies. The research contributes to the broader understanding of biomarker responses for environmental monitoring.
The journal Cite Score is (6.6), Impact factor (2.8).
The article can be found in the following link: https://doi.org/10.1002/jat.4936
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