زانکۆی جیهان – سلێمانی پلەی یەکەمی ڕیزبەندی Impact Ranking لە پارێزگای سلێمانی بەدەستهێنا
Dr. Anvar Soleimani, a lecturer and Researcher at the Department of Medical Microbiology, College of Health Sciences, Cihan University-Sulaimaniya, has published an article in the esteemed Journal of Molecular and Cellular Biochemistry. This Review article provides a comprehensive analysis of molecular mechanisms that sustain MAPK activation and promote tamoxifen resistance. Tamoxifen remains a standard treatment for estrogen receptor (ER)-positive breast cancer. However, many patients develop resistance, even without changes to the ER itself. The research highlights how persistent MAPK signalling, driven by factors such as growth factors, RNA-binding proteins, microRNAs, and mitochondrial changes, enables cancer cells to evade tamoxifen’s effects. The study also discusses how MAPK, in cooperation with other survival pathways like PI3K/AKT and receptor tyrosine kinases (EGFR, IGF-1R, FGFR), creates redundant networks that promote tumor survival. Importantly, the authors identify potential therapeutic strategies, including MAPK-targeting drugs and RNA-based treatments, that may help overcome this resistance.
The journal is indexed in Scopus (Q1) and Cite Score of 8.3, an Impact Factor of 3.5. The article can be found in the following links:
https://link.springer.com/article/10.1007/s11010-025-05304-0
Related posts
